Passage of Inhaled Particles Into the Blood Circulation in Humans Circulation v.105, n.4, 29jan02
نویسنده
چکیده
Methods and Results—To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioactivity after the inhalation of “Technegas,” an aerosol consisting mainly of ultrafine 99mTechnetium-labeled carbon particles ( 100 nm). Radioactivity was detected in blood already at 1 minute, reached a maximum between 10 and 20 minutes, and remained at this level up to 60 minutes. Thin layer chromatography of blood showed that in addition to a species corresponding to oxidized 99mTc, ie, pertechnetate, there was also a species corresponding to particle-bound 99mTc. Gamma camera images showed substantial radioactivity over the liver and other areas of the body.
منابع مشابه
Passage of inhaled particles into the blood circulation in humans.
BACKGROUND Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioact...
متن کاملPassage of Inhaled Particles Into the Blood Circulation in Humans
Background—Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. Methods and Results—To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioactiv...
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